diff --git a/doc/install.rst b/doc/install.rst
index 6c66ec1ebcea80289896c3a44fe9c5bb88896373..cf5e582553710e1760975f36b0e484217eff38ea 100644
--- a/doc/install.rst
+++ b/doc/install.rst
@@ -61,7 +61,9 @@ Choose the relevant tab for details on each of those installation paths.
       pixi install --frozen --environment cuda
       pixi run -e cuda mednet info
 
-   Refer to further pixi configuration tips on the *Development* tab above.
+   To enable CUDA support, always run applications using the ``cuda``
+   environment via ``pixi run -e cuda ...``.  Refer to further pixi
+   configuration tips on the *Development* tab above.
 
 
 .. _mednet.setup: